File:Anaesthetic-Tricaine-Acts-Preferentially-on-Neural-Voltage-Gated-Sodium-Channels-and-Fails-to-Block-pone.0103751.s001.ogv

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Original file ‎(Ogg multiplexed audio/video file, Theora/Vorbis, length 1 min 23 s, 1,280 × 720 pixels, 815 kbps overall, file size: 8.09 MB)


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Summary

Description
English: Movement of wild type (wt), fixe mutants (chrndsb13/sb13) or fixe sibling (chrndsb13/+ or chrnd+/+) fish in response to EES. Fish were treated with the water control or tricaine at standard or fivefold dose, as indicated before each clip. A pulse train of 0.1 s duration was applied every 5 seconds. Movie is sped up about 2.5-fold for ease of viewing. Note increased movement in response to the first pulse, possibly reflecting the need for channel activation for tricaine to bind to Nav channels. Heartbeat shows all fish are alive. In ‘fixe + 5X tricaine' clip, heartbeat shows fish are alive but fail to respond to stimulation.
Date
Source Movie S1 from Attili S, Hughes S (2014). "Anaesthetic Tricaine Acts Preferentially on Neural Voltage-Gated Sodium Channels and Fails to Block Directly Evoked Muscle Contraction". PLOS ONE. DOI:10.1371/journal.pone.0103751. PMID 25090007. PMC: 4121177.
Author Attili S, Hughes S
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8,480,216 byte

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current22:25, 8 August 20141 min 23 s, 1,280 × 720 (8.09 MB)Open Access Media Importer BotAutomatically uploaded media file from Open Access source. Please report problems or suggestions here.

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