File:Dual-inhibition-of-HIV-1-replication-by-integrase-LEDGF-allosteric-inhibitors-is-predominant-at-the-1742-4690-10-144-S2.ogv

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Dual-inhibition-of-HIV-1-replication-by-integrase-LEDGF-allosteric-inhibitors-is-predominant-at-the-1742-4690-10-144-S2.ogv ‎(Ogg multiplexed audio/video file, Theora/Vorbis, length 43 s, 320 × 240 pixels, 295 kbps overall, file size: 1.52 MB)


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Description
English: The movie was generated with PyMOL [73]. The intermediate structures between the initial and final state where generated using the morphing option in Pymol. The two IN monomers are colored in red and gold. The magnesium ion is represented as a green sphere and the coordinating residues of the magnesium and in the Mut101 pocket are represented in sticks. The solvent accessible surface coloring is in red and gold for the carbon atom of the corresponding monomer with the nitrogen in blue, the oxygen in red and sulfur in yellow. Mut101 is represented in cyan.
Date
Source Video file from Le Rouzic E, Bonnard D, Chasset S, Bruneau J, Chevreuil F, Le Strat F, Nguyen J, Beauvoir R, Amadori C, Brias J, Vomscheid S, Eiler S, Levy N, Delelis O, Deprez E, Saib A, Zamborlini A, Emiliani S, Ruff M, Ledoussal B, Moreau F, Benarous R (2013). "Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage". Retrovirology. DOI:10.1186/1742-4690-10-144. PMID 24261564. PMC: 4222603.
Author Le Rouzic E, Bonnard D, Chasset S, Bruneau J, Chevreuil F, Le Strat F, Nguyen J, Beauvoir R, Amadori C, Brias J, Vomscheid S, Eiler S, Levy N, Delelis O, Deprez E, Saib A, Zamborlini A, Emiliani S, Ruff M, Ledoussal B, Moreau F, Benarous R
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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Date/TimeThumbnailDimensionsUserComment
current05:48, 14 November 201443 s, 320 × 240 (1.52 MB)Open Access Media Importer BotAutomatically uploaded media file from Open Access source. Please report problems or suggestions here.

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