File:Feasibility-and-Safety-of-Continuous-and-Chronic-Bilateral-Deep-Brain-Stimulation-of-the-Medial-256196.f1.ogv

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Original file ‎(Ogg Theora video file, length 1 min 0 s, 1,280 × 720 pixels, 4.92 Mbps, file size: 35.26 MB)


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Summary

Description
English: The video clip presents SEEKING behavior induced by chronic continuous bilateral bipolar stimulation of the medial forebrain bundle in a rat, during the titration phase of our stimulation protocol. The video starts showing the animal's expected behavior in OFF condition. During the first few seconds of stimulation ON, visual fixation and freezing behavior can be observed, followed immediately by intensive sniffing and subsequent persistent explorative behavior of the home-cage and surrounding environment. The anti-TH micrographs enclosed in the video indicate the positioning of the stimulating electrodes in the MFB. MFB: Medial Forebrain Bundle; NAC: Nucleus Accumbens; CPu: Striatum; SNc: Substantia Nigra pars compacta; VTA: Ventral Tegmental Area; RRF: Retrorubral field. Yellow spots on the micrographs schematically represent the electric field within the stimulated area.
Date
Source Video file from Furlanetti L, Döbrössy M, Aranda I, Coenen V (2015). "Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat". Behavioural Neurology. DOI:10.1155/2015/256196. PMID 25960609. PMC: 4414266.
Author Furlanetti L, Döbrössy M, Aranda I, Coenen V
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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current17:21, 12 May 20151 min 0 s, 1,280 × 720 (35.26 MB)Open Access Media Importer BotAutomatically uploaded media file from Open Access source. Please report problems or suggestions here.

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